Faculty Awards Willa Dean Lowery Grant

Willa Dean Lowery Awards 2022

We congratulate our winners of the 2022 Willa Dean Lowery Fund to Support Research in the Natural Sciences:

Roslyn Crowder, Associate Professor of Biology

Examining Hypoxia-Induced Caspase-8 Post-Translational Modifications in Hypoxic Cancer Cells

Caspase-8 is a mediator of regulated cell death, apoptosis. Caspase-8 mediated cell death is used clinically to target and eliminate pathogenic cells in diseases including cancer, lupus and rheumatoid arthritis. Loss of caspase-8 activity has been identified as a cell death resistance mechanism, highlighting the requirement of complete caspase-8 activation for cell death progression. Hypoxia is a term that refers to conditions with low oxygen levels. Hypoxic regions in solid, malignant tumors have been found to be resistant to chemotherapy and radiation therapy, presenting therapeutic challenges. Chemotherapy and radiation therapy utilize initiation of cell death pathways involving caspase-8 activation to kill cancer cells.

Caspase-8 protein receives several post-translational modifications (PTMs) that effect protein function including phosphorylation (adds phosphates), ubiquitination (adds ubiquitin) and sumoylation (adds SUMO). Cullin3 ligase and A20 deubiquitinase are associated with adding and removing ubiquitin to and from caspase-8, respectively. PIAS ligase and SUMO specific protease SENP1 are associated with adding and removing SUMO to and from caspase-8, respectively. Hypoxia has been shown to alter protein phosphorylation. While changes to phosphorylated proteins under hypoxia have been studied, changes to ubiquitinated and sumoylated proteins, remain largely unexplored. Regulation of caspase-8 sumoylation and ubiquitination, under hypoxia, has not been investigated.

ACE Women's Network

ACE Women’s Network Florida’s 5th Annual State Conference

We are excited to share the registration link for the ACE Women’s Network Florida’s 5th Annual State Conference.

If you have attended one of our conferences in the past, then you know that you’re in for a half-day jam-packed with an inspirational keynote from a sitting university president, informative and interactive leadership development workshops, and opportunities to expand your professional network.

Limited scholarships to cover the registration fee are available, thanks to the generous support of Prez Roellke. Apply here on/before April 7, 2022

Tap the EventBrite link to join us and/or share with a colleague and your professional networks. Questions? Contact [email protected] or [email protected]