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Willa Dean Lowery Awards 2024

Kristine Dye, Assistant Professor of Health Sciences and Biology

Identification of a Non-Canonical Nuclear Localization Signal in the Merkel Cell Polyomavirus Small Tumor Antigen Necessary for the Development of Merkel Cell Carcinoma

Merkel Cell Polyomavirus (MCPyV) is the most recently discovered human oncogenic virus, and the etiologic agent of Merkel Cell Carcinoma (MCC), a skin cancer three times more deadly than melanoma. Previous work at Stetson found the small tumor antigen (ST) of MCPyV to be responsible for the development of MCC. Using an innovative dissimilarity approach, it was found that MCPyV ST is uniquely oncogenic when compared to the ST antigens of other human polyomaviruses. Furthermore, it was found that MCPyV ST uniquely localizes to the nucleus despite the absence of a nuclear localization sequence (NLS) and that this localization is necessary for oncogenesis. Future studies aim to identify the novel NLS of MCPyV ST, and determine whether this non-canonical NLS is responsible for the unique oncogenic abilities of MCPyV, necessary for the development of MCC. Consequently, these findings may support the development of novel MCPyV targeted therapeutics necessary for the treatment of MCC.

Lynn Kee, Associate Professor of Biology

Investigating TOR ell Signaling and the Effects of Rapamycin on Painted Lady Caterpillar and Butterfly Development

TOR signaling has been studied extensively in other organisms, and collectively, studies show that TOR regulates cell growth, aging, and survival in many organisms. In mice, treatment with rapamycin, a chemical that inhibits TOR signaling results in mice that lived 28% to 38% longer than the control group, which is about 6 to 9 years in human years. Studies in other organisms have shown similar effects of rapamycin on aging, a phenomenon conserved from yeast to worms to flies to mice. Our initial studies have shown that rapamycin treatment with Vanessa Cardui caterpillars lead to longer lived caterpillars with 30% increase in lifespan. The caterpillars form a chrysalis but we observed a failure of butterflies to hatch out of the chrysalises. Whether the butterflies cannot escape due to impaired or delayed wing development is not known. Here, we aim to investigate rapamycin’s effect on caterpillar and butterfly development, and TOR signaling. We propose to test different concentrations of rapamycin on caterpillar and butterfly development. In addition, we aim to measure the effect of rapamycin treatment on TOR signaling components through biochemical protein assays. Collectively, these studies will be the first study to investigate how TOR inhibition with rapamycin affects the development and lifespan of caterpillars and butterflies.

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Willa Dean Lowery Awards 2023

Holley Lynch, Associate Professor of Physics

Establishing Vanessa Cardui as a System for Embryo Research

Painted lady butterflies, Vanessa Cardui, are ideal for research with undergraduate students because butterflies are invertebrates with a relatively fast life cycle that lay eggs every day for several weeks at a time. Currently, Dr. Lynn Kee’s lab observations of the effect of genetic changes were all done at the caterpillar stage and beyond. Last year, we successfully collected the first images of embryo development in this species. This project will build on that success by making V. Cardui embryos a flexible system for student and faculty researchers by establishing temperature-based staging charts and developing a protocol to access tissues and cells in a living embryo. Achieving the first aim will allow researchers to schedule experiments to take advantage of peak egg-laying times regardless of the interest stage. Completing the second aim will allow the use of biophysical techniques from

imaging to mechanical manipulation on these embryos. This project has the potential to have a huge impact on the field by taking live images of cell movements at the embryo stage for any butterfly species.

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2024 Hand Award for Distinguished faculty Achievement.

Stetson University proudly announces the winners of the 2024 Hand Awards for Distinguished Faculty Achievement. These annual awards recognize outstanding faculty for their contributions in community impact, research, and professional activities. Congratulations to this year’s honorees:

Hand Award for Community Impact

Wendy Anderson, Professor of Environmental Science and Studies

The 2024 Hand Award for Community Impact recognizes a faculty member who came to Stetson University in 2014 as a department chair. In her almost 10 years at Stetson, she has achieved a distinguished record of community service, becoming a vital public figure and environmental champion in the broader West Volusia community. She chairs the Volusia Soil and Water Conservation District Board of Supervisors, contributes a regular column to The West Volusia Beacon about locally relevant environmental issues, and serves on two advisory panels tasked with land management. She has also served on the Volusia County Environmental and Natural Resource Advisory Committee. Her ability to bridge political divides and navigate complex bureaucracies in the name of safeguarding the region’s shared natural and water resources is truly commendable. In so doing, she has enhanced Stetson’s profile, further advancing the university’s mission and values. This environmental scientist is described as a consummate community-engaged teacher-scholar, leveraging both her community connections and environmental expertise to enrich her students’ educational experiences. At Stetson, she reimagined the structure of the Department of Environmental Science and Studies and was instrumental in the creation of the Sustainable Food Systems Program. In her nomination packet, boasting numerous letters of support from faculty, staff, students, and DeLand community collaborators, multiple nominators refer to this faculty member as a “force of nature,” with one supporter noting that her level of community engagement is “nothing short of extraordinary.” Her primary nominator summarized her vast qualifications as follows: “I am honored and proud to work with her in the same department, where she effectively

showcases science in action. She embodies a conscientious scientist who takes her knowledge to streets, communities, city hall meetings, and her classrooms with the ultimate goal of passionately serving humanity. She has taught her students, in action, how to engage with individuals in positions of power and policymakers, compelling them to listen and take action to safeguard our shared environment.  

For her professional commitment and her exceptional contributions to the university and broader communities, it gives me great pleasure on behalf of the faculty, staff, and students at Stetson University to present the 2024 Hand Award for Community Impact to Professor and Chair of Environmental Science and Studies and Director of the Sustainable Food Systems Program, Dr. Wendy Anderson.

Hand Award for Research, Creative, and Professional Activity

Dr. Carol Azab, Associate Professor of Marketing

The first 2024 Hand Award for Research, Creative and Professional Activity recognizes an outstanding faculty member who – in her short time at Stetson University – has established herself as one of the most productive scholars in the School of Business Administration. This faculty member’s scholarly inquiry focuses on services marketing, global marketing, and the influence of the marketing function within the firm and the discipline. A hallmark of scholarly pursuits is peer review – the sharing and public testing of scholarly inquiry. The exceptional quality of this researcher’s scholarship is evidenced by the successful acceptance of 10 peer-reviewed journal articles in just eight years. Seven of her 10 papers have appeared in the most prestigious top-tier journals in the field, including the Journal of Business Research, the Journal of Consumer Behaviour, the Journal of Business Ethics, and the Journal of Behavioral Finance. These journals enjoy some of the highest impact factors, which are proxy measures of the importance, deep rigor, international reach, and appeal of the published research. One of her articles – on new rules of social media shopping – garnered the distinction of the most cited paper in the Journal of Consumer Behaviour in 2022, for which she won an award. By pursuing research projects with current and former colleagues, and supervising at least eight student research groups annually, her

students have benefited significantly from her expertise in a broad set of analytical techniques. More specifically, her work in services marketing has helped redefine disciplinary knowledge and as a teacher-scholar, she has brought her findings to the classroom and transformed her marketing courses. In sum, her work has influenced the direction and evolution of her discipline. One faculty nominator wrote, “[This scholar] is passionate about justice in service recovery, establishing equity when companies fail customers’ expectations and [are] trying to win them back. Her research is significant because it deals with stereotypes of minority customers and the use of primary and secondary language in service encounters.”

Through her stellar scholarship and impressive service to her field, this faculty member contributes impressively to Stetson University’s scholarly and intellectual vibrancy. In 2023, she received the School of Business Administration’s Outstanding Researcher of the Year Award. It gives me great pleasure on behalf of the faculty and staff at Stetson University to present the 2024 Hand Award for Research, Creative, and Professional Activity to Associate Professor Dr. Carol Azab  for her professional commitment and her exceptional scholarly contributions.

Hand Award for Research, Creative and Professional Activity

Jean Smith, Assistant Professor of Biology

The second 2024 Hand Award for Research, Creative and Professional Activity honors a faculty member who has rapidly established herself as a leading scientific researcher and whose quality of research has had a transformative impact on the field of molecular biology. Since arriving at Stetson University in 2019, this scientist has acquired an impressive publication record by repeatedly publishing her research outcomes in top-tier, high impact scientific journals, including Science, Genetics, and The Journal of Cell Biology. Within the past five years her body of research has been cited in the published works of other scientists approximately 500 times. Furthermore, she has garnered major grant support including a recent multi-year award from the National Science Foundation for more than half a million dollars. As a Stetson University teacher-scholar, this faculty member has demonstrated the unique integration of the teacher’s facilitation of students’ learning with her own continuous scholarly development in two ways. First, her involvement of students as researchers in

her own professional development has led to ground-breaking research in molecular biology, and the team’s work has led to novel findings in the molecular mechanisms of cell fusion—a process essential for sexual reproduction in all organisms. Seven of her mentored research students have won best student presentation awards at scientific conferences. Second, her scholarly work infuses her courses with research-rich experiential learning opportunities for students. This is particularly noteworthy in her Genetics and Microbiology offerings—two courses that now form a vital core of Stetson’s extremely successful health professions curriculum. Several of her students have been recruited into the nation’s top graduate programs. One faculty nominator wrote: “She is an exemplar of the way in which an excellent, rigorous scientist can mentor and excite students, introducing them to concepts they may have never considered, and making the previously inconceivable understandable and attainable”.

It gives me great pleasure on behalf of the faculty and staff at Stetson University to present the 2024 Hand Award for Research, Creative, and Professional Activity to Assistant Professor Dr. Jean Smith  for her professional commitment and her exceptional scholarly contributions.